Can't speak for everyone, but it doesn't bother me. I have very strong opinions and beliefs, but no formal religion and I think we make our own choices, not our Higher Power. I believe we are here to make our own path and our behaviors/decisions are on us.It's common for people to question their beliefs during hard times. Unfortunately, I think you will find that it is up to you, your ex and your children to make your lives better. Sitting and waiting for God to do it, probably will continue to frustrate you.
You mentioned your wife and substance abuse. Are you 100% positive that she did not drink or take a ny other drugs when she was pregnant? There can be actual brain damage due to alcohol ingested while a woman is pregnant and it only takes one time. Usually it is more though. Have you ever heard of fetal alcohol spectrum?
As for Sister, talk to US. If your sister is normally mean and toxic to you I'd go low to no contact with her or anybody who is not helpful to you right now. That is not the sort of "help" you need.