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Iron Deficiency in ADHD children
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<blockquote data-quote="Malika" data-source="post: 428764" data-attributes="member: 11227"><p>[FONT=verdana, arial, helvetica, sans-serif]<span style="font-size: 15px"><span style="color: #003399"><strong><span style="font-size: 10px">As a footnote to my previous post, here is an abstract of one of these studies</span></strong></span></span></p><p><span style="font-size: 15px"><span style="color: #003399"><strong></strong></span></span></p><p><span style="font-size: 15px"><span style="color: #003399"><strong>Iron Deficiency in Children With Attention-Deficit/Hyperactivity Disorder </strong></span></span>[/FONT] [FONT=verdana, arial, helvetica, sans-serif]<span style="font-size: 10px"><a href="http://archpedi.ama-assn.org/cgi/content/full/158/12/1113#AUTHINFO" target="_blank"> Eric Konofal, MD, PhD; Michel Lecendreux, MD; Isabelle Arnulf, MD, PhD; Marie-Christine Mouren, MD </a></span>[/FONT]</p><p> </p><p>[FONT=verdana, arial, helvetica, sans-serif]<span style="font-size: 10px"> <em>Arch Pediatr Adolesc medication.</em> 2004;158:1113-1115. </span>[/FONT]</p><p> [FONT=verdana, arial, helvetica, sans-serif]<span style="font-size: 10px"><span style="color: #003399"><strong> ABSTRACT </strong></span></span>[/FONT] </p><p> </p><p> [FONT=verdana, arial, helvetica, sans-serif]<span style="font-size: 10px"> <strong>Background </strong> Iron deficiency causes abnormal dopaminergic neurotransmission and may contribute to the physiopathology of attention-deficit/hyperactivity disorder (ADHD). </span>[/FONT] [FONT=verdana, arial, helvetica, sans-serif]<span style="font-size: 10px"><strong>Objective </strong> To evaluate iron deficiency in children with ADHD vs iron deficiency in an age- and sex-matched control group. </span>[/FONT]</p><p> [FONT=verdana, arial, helvetica, sans-serif]<span style="font-size: 10px"><strong>Design </strong> Controlled group comparison study. </span>[/FONT]</p><p> [FONT=verdana, arial, helvetica, sans-serif]<span style="font-size: 10px"><strong>Setting </strong> Child and Adolescent Psychopathology Department in European Pediatric Hospital, Paris, France. </span>[/FONT]</p><p> [FONT=verdana, arial, helvetica, sans-serif]<span style="font-size: 10px"><strong>Patients </strong> Fifty-three children with ADHD aged 4 to 14 years (mean ± SD, 9.2 ± 2.2 years) and 27 controls (mean ± SD, 9.5 ± 2.8 years). </span>[/FONT]</p><p> [FONT=verdana, arial, helvetica, sans-serif]<span style="font-size: 10px"><strong>Main Outcome Measures </strong> Serum ferritin levels evaluating iron stores and Conners Parent Rating Scale scores measuring severity of ADHD symptoms have been obtained. </span>[/FONT]</p><p> [FONT=verdana, arial, helvetica, sans-serif]<span style="font-size: 10px"><strong>Results </strong> The mean serum ferritin levels were lower in the children with ADHD (mean ± SD, 23 ± 13 ng/mL) than in the controls (mean ± SD, 44 ± 22 ng/mL; <em>P</em> < .001). Serum ferritin levels were abnormal (<30 ng/mL) in 84% of children with ADHD and 18% of controls (<em>P</em> < .001). In addition, low serum ferritin levels were correlated with more severe general ADHD symptoms measured with Conners Parent Rating Scale (Pearson correlation coefficient, <em>r</em> = 0.34; <em>P</em> < .02) and greater cognitive deficits (<em>r</em> = 0.38; <em>P</em> < .01). </span>[/FONT]</p><p> [FONT=verdana, arial, helvetica, sans-serif]<span style="font-size: 10px"><strong>Conclusions </strong> These results suggest that low iron stores contribute to ADHD and that ADHD children may benefit from iron supplementation. </span>[/FONT]</p><p> </p><p> [FONT=verdana, arial, helvetica, sans-serif]<span style="font-size: 10px"> </span></p><p><span style="font-size: 10px">[FONT=verdana, arial, helvetica, sans-serif][/FONT]</span>[/FONT]</p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p>[FONT=verdana,arial,helvetica,sans-serif]<span style="font-size: 9px"><a href="http://archpedi.ama-assn.org/cgi/content/full/158/12/1113#BIBL" target="_blank">http://archpedi.ama-assn.org/cgi/content/full/158/12/1113#BIBL</a></span>[/FONT]</p><p> <img src="http://archpedi.ama-assn.org/icons/spacer.gif" alt="" class="fr-fic fr-dii fr-draggable " style="" /> <img src="http://archpedi.ama-assn.org/icons/spacer.gif" alt="" class="fr-fic fr-dii fr-draggable " style="" /> <img src="http://archpedi.ama-assn.org/icons/spacer.gif" alt="" class="fr-fic fr-dii fr-draggable " style="" /> [FONT=verdana, arial, helvetica, sans-serif] [/FONT]</p></blockquote><p></p>
[QUOTE="Malika, post: 428764, member: 11227"] [FONT=verdana, arial, helvetica, sans-serif][SIZE=4][COLOR=#003399][B][SIZE=2]As a footnote to my previous post, here is an abstract of one of these studies[/SIZE] Iron Deficiency in Children With Attention-Deficit/Hyperactivity Disorder [/B][/COLOR][/SIZE][/FONT] [FONT=verdana, arial, helvetica, sans-serif][SIZE=2][URL="http://archpedi.ama-assn.org/cgi/content/full/158/12/1113#AUTHINFO"] Eric Konofal, MD, PhD; Michel Lecendreux, MD; Isabelle Arnulf, MD, PhD; Marie-Christine Mouren, MD [/URL][/SIZE][/FONT] [FONT=verdana, arial, helvetica, sans-serif][SIZE=2] [I]Arch Pediatr Adolesc medication.[/I] 2004;158:1113-1115. [/SIZE][/FONT] [FONT=verdana, arial, helvetica, sans-serif][SIZE=2][COLOR=#003399][B] ABSTRACT [/B][/COLOR][/SIZE][/FONT] [FONT=verdana, arial, helvetica, sans-serif][SIZE=2] [B]Background [/B] Iron deficiency causes abnormal dopaminergic neurotransmission and may contribute to the physiopathology of attention-deficit/hyperactivity disorder (ADHD). [/SIZE][/FONT] [FONT=verdana, arial, helvetica, sans-serif][SIZE=2][B]Objective [/B] To evaluate iron deficiency in children with ADHD vs iron deficiency in an age- and sex-matched control group. [/SIZE][/FONT] [FONT=verdana, arial, helvetica, sans-serif][SIZE=2][B]Design [/B] Controlled group comparison study. [/SIZE][/FONT] [FONT=verdana, arial, helvetica, sans-serif][SIZE=2][B]Setting [/B] Child and Adolescent Psychopathology Department in European Pediatric Hospital, Paris, France. [/SIZE][/FONT] [FONT=verdana, arial, helvetica, sans-serif][SIZE=2][B]Patients [/B] Fifty-three children with ADHD aged 4 to 14 years (mean ± SD, 9.2 ± 2.2 years) and 27 controls (mean ± SD, 9.5 ± 2.8 years). [/SIZE][/FONT] [FONT=verdana, arial, helvetica, sans-serif][SIZE=2][B]Main Outcome Measures [/B] Serum ferritin levels evaluating iron stores and Conners Parent Rating Scale scores measuring severity of ADHD symptoms have been obtained. [/SIZE][/FONT] [FONT=verdana, arial, helvetica, sans-serif][SIZE=2][B]Results [/B] The mean serum ferritin levels were lower in the children with ADHD (mean ± SD, 23 ± 13 ng/mL) than in the controls (mean ± SD, 44 ± 22 ng/mL; [I]P[/I] < .001). Serum ferritin levels were abnormal (<30 ng/mL) in 84% of children with ADHD and 18% of controls ([I]P[/I] < .001). In addition, low serum ferritin levels were correlated with more severe general ADHD symptoms measured with Conners Parent Rating Scale (Pearson correlation coefficient, [I]r[/I] = 0.34; [I]P[/I] < .02) and greater cognitive deficits ([I]r[/I] = 0.38; [I]P[/I] < .01). [/SIZE][/FONT] [FONT=verdana, arial, helvetica, sans-serif][SIZE=2][B]Conclusions [/B] These results suggest that low iron stores contribute to ADHD and that ADHD children may benefit from iron supplementation. [/SIZE][/FONT] [FONT=verdana, arial, helvetica, sans-serif][SIZE=2] [FONT=verdana, arial, helvetica, sans-serif][SIZE=2][COLOR=#003399][/COLOR][/SIZE][/FONT][/SIZE][/FONT] [FONT=verdana,arial,helvetica,sans-serif][SIZE=1][URL="http://archpedi.ama-assn.org/cgi/content/full/158/12/1113#BIBL"][/URL][/SIZE][/FONT] [IMG]http://archpedi.ama-assn.org/icons/spacer.gif[/IMG] [IMG]http://archpedi.ama-assn.org/icons/spacer.gif[/IMG] [IMG]http://archpedi.ama-assn.org/icons/spacer.gif[/IMG] [FONT=verdana, arial, helvetica, sans-serif][SIZE=2] [/SIZE][/FONT] [/QUOTE]
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