I don't know.
As Mrs. 200Meters & I were plowing through fertility treatments (9 IVFs, 2 FETs, AIH, etc. all failed; cost isn't really an issue here in Israel), we registered for adoption. (All domestic adoptions in Israel are, by law, public and closed. Legislation for foreign adoption hadn't been passed yet and even if it had, we couldn't have afforded it.) Thus Oldest and Youngest (whom we received at 2 months & 2.5 weeks, respectively). We were the first couple in our little group to get married & the last to have children. Being childless was really starting to eat at us. We were over the moon when we received Oldest & Youngest.
Now, I sometimes wonder if the fact Mrs. 200Meters & I can't have biological children wasn't G-d's way of telling us that, for whatever reason, we were not meant to be parents and that perhaps we would have been better off if we had taken His hint. I dunno. Hindsight is always 20/20.
But I think about it.