I nearly died back in 06 of a hospital acquired infection after major surgery. Luckily "my" infection responded to antibiotics.
Best thing you can do is watch (or have someone watch) all the hospital personnel that come in your room. Make sure all wash hands and change to fresh gloves.
Don't hesitate to speak up.
At home? Practice good hygiene, especially as regards food handling. If you eat meat, use a seperate cutting board for meat and do not use a wood board for meat.
Clean the meat board with a 5% bleach solution. Also disinfect utensils used to prepare raw meat.
Wash hands in between handling meat/fish, and handling veggies/fruit. This avoids cross-contamination.
If you use a slow-cooker, check with a thermometer to be certain that the cooker can maintain a temp of 165 degrees.
If you have a dishwasher, use it! Most dishwashers get hot enough to sanitize dishes, etc.
Wash hands after playing with pets, especially reptiles and birds, and before handling food.
Bathroom hygiene shouldn't need to be explained.
Eat a clean diet, avoiding meats that have been raised on anti-biotics and especially avoiding farm-raised fish and shellfish, which are loaded with bacteria, antibiotics, and other nasty stuff.
Before my infection in 06, the only antibiotics I'd taken other than in food, had been pennicillins and sulfas. The infection was cleared up with Flagyl.
So, three antibiotics in my lifetime.
Then, last year, a cat scratch on my left leg got infected. My leg turned red and swelled up.
Went to doctor and found out I had cellulitis. Took trials of 4 antibiotics before we found one that worked against the bug (Strep B), and it made me sicker than a dog.
I hadn't been in the hospital, hadn't been to a foreign country, and Squeaky, who scratched me playing, hadn't been out of the house other than trips to the vet and the move in the years I've had her.
Yet, somehow, this nasty, antibiotic resistant version of a common bug, was living "in the wild" and was either on Squeaky's claws, or had somehow found its way into my home.
All you can do is be "hygenic", only take antibiotics when needed and prescribed, and try to avoid antibiotics in your environment such as in food.
You can help protect friends and loved ones by watching and speaking up if you visit them in the hospital.
Oh, another thing. Don't shave if you don't have to. Shaving opens microscopic scrapes and cuts all over the shaved area and shaven people are much more prone to skin infections like cellulitis.